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Which of the following will be unchanged in a Lineweaver-Burk plot of an enzyme with and without a competitive
inhibitor?
A. Km
B. Slope
C. x-intercept
D. y-intercept
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Can anyone explain te answer?]
thx
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competitive inhibitors resemble the substrate and compete for binging to the active site of the enzyme. They increase Km, but have no effect on Vmax. So in Lineweaver-Burk plot, the Y-intercept which stands for 1/Vmax keeps unchanged.