Estrogen replacement therapy - artepupila

[ArchivalUser]

Can somebody explain to me the Estrogenen risk. I found out some discrepancy. Every study has different conclusion.

Thaks.

[ArchivalUser]

Do not use estrogen treatment if you:

Are pregnant.
Have unexplained vaginal bleeding.
Have active liver disease or chronic impaired liver function. (Transdermal estrogen does not stress the liver.)
Have a personal history of breast cancer or endometrial cancer.
Are a smoker.


Risks of estrogen replacement therapy
Systemic estrogen replacement therapy increases your risks of:3

Stroke. ERT use slightly increases the risk of stroke during the first year of use.5
Blood clots. ERT slightly increases the risk of blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism), which can be life-threatening. This risk is greatest in the first year of use.6 A recent small study suggests that oral ERT slightly increases blood clot risk, but the ERT patch does not. When taken orally, ERT seems to increase a clotting factor in the blood; this does not happen with ERT that is absorbed through the skin.7
Breast cancer. The Million Women Study has shown that, in women using ERT for 10 years, the number of breast cancers is slightly higher than in women not taking ERT.8 Although the Women's Health Initiative (WHI) trial found no increase in breast cancer over 7 years of ERT use, experts continue to take the breast cancer risk seriously.9
Uterine (endometrial) cancer (only if you have a uterus). Taking progestin with estrogen eliminates this risk.8
Gallstones. Women who use estrogen replacement therapy are more likely to have gallstones that cause symptoms than women who do not use ERT. (High estrogen levels are linked to gallbladder disease.)
Ovarian cancer (which is rare). Fatal ovarian cancer increases from 26 women per 100,000 who never used estrogen to 64 women per 100,000 who used estrogen for 10 years or longer.10
ERT breast cancer risk is lower than the estrogen-progestin (HRT) breast cancer risk. In the British Million Women study of women who took hormone therapy for 10 years till age 60:8

Estrogen-progestin use increased breast cancer by 19 per 1,000 women.
Estrogen-alone use increased breast cancer by 5 per 1,000 women.

[ArchivalUser]

Thank you very much.