physio q - drkap

[ArchivalUser]

2. A high plasma Ca2+ level causes

(A) bone demineralization

(B) increased formation of 1,25-dihydroxycholecalciferol

© decreased secretion of calcitonin

(D) decreased blood coagulability

(E) increased formation of 24,25-dihydroxycholecalciferol

[ArchivalUser]

e....

[ArchivalUser]

it is E

[ArchivalUser]

yes its E.

[ArchivalUser]

ee

[ArchivalUser]

can any one explain it

[ArchivalUser]

as far as i know hypercalsaemia of hyper parathyroidism cases bone demineralisation

[ArchivalUser]

increase Ca2+ cause downregulation of vit. D synthesis in the kidney --> decrease in activation of 25-hydroxycalciferol coming from liver to the active form vit. D which is 1,25 dihydroxycholecalciferol --> instead there will be an increase in formation of the inactive form of vit. D which is 24,25-dihydroxycholecalciferol

[ArchivalUser]

thanks