A 69-year-old terminally ill man with liver failur - belkin

[ArchivalUser]

A 69-year-old terminally ill man with liver failure is given a baboon liver transplant. After 1 week, he shows signs of rejection. This patient™s rejection is most likely mediated by which of the following?

A. Action of complement and other serum mediators
B. Action of neutrophils
C. Combination of T lymphocytes and antibody-mediated mechanisms
D. Preformed antibodies
E. T lymphocytes
F. Macrophages

[ArchivalUser]

E.

[ArchivalUser]

E...

[ArchivalUser]

Option E (T lymphocytes) is correct. Transplants can be categorized as xenografts (from different species, e.g., pig, baboon), allografts (from unrelated members of the same species), isografts (from an identical twin), and autografts (from a different part of the same person). Organ rejections can be categorized as hyperacute (occurring immediately after transplantation), acute (occurring 1 to 3 weeks after transplantation), and chronic (occurring months or years after transplantation). In this case, the patient™s transplant is a xenograft, and he is suffering from acute rejection. Acute rejections are mediated by activation of T lymphocytes.

[ArchivalUser]

acute rejection?