09-11-2007, 03:06 PM
A 33-year-old woman presents with symmetrically swollen, red and painful joints in the fingers, hands, and wrists and bilateral nodular lesions on the elbows. She also complains about morning stiffness and muscle pain as well as xerophthalmia and xerostomia. Her ESR is 45 mm per hour and her serum rheumatoid factor is 100 U/mL. Antibodies against which antigen may have contributed to the pathogenesis of this patient's condition?
A. IgA antibodies directed against synovial cells
B. IgG antibodies directed against small nuclear ribonucleoproteins
C. IgG antibodies directed against ssDNA
D. IgM antibodies directed against histones
E. IgM antibodies directed against IgG antibodies
A. IgA antibodies directed against synovial cells
B. IgG antibodies directed against small nuclear ribonucleoproteins
C. IgG antibodies directed against ssDNA
D. IgM antibodies directed against histones
E. IgM antibodies directed against IgG antibodies