11-24-2007, 05:33 AM
A case-control study is conducted to assess the
risk for
intussusception in infants under the age of 1 year who
receive the rotavirus
vaccine. The medical records of all those who
received the vaccine and
those who did not receive the vaccine over a 6-month
period are
reviewed. Results show 125 cases per 100,000
infant-years for infants who
received the vaccine compared to 45 cases per 100,000
infant-years for
infants who did not receive the vaccine. The
investigators conclude that
the relative risk for intussusception is 1.9 times
greater in infants
who receive the rotavirus vaccine (95% confidence
interval of 0.5“7.7 and
p=0.39). Which of the following is the most accurate
interpretation of
these results?
A
) The results do not show an association between
rotavirus vaccine
and intussusception, but they may be related
B
) The results show sufficient statistical power to
identify an
association between rotavirus vaccine and
intussusception
C
) Rotavirus vaccine is associated with a 39% risk
for
intussusception
D
) Rotavirus vaccine causes intussusception in 1.9%
of infants
E
) Rotavirus vaccine prevents 80 cases of
intussusception per 100,000
infant-years
risk for
intussusception in infants under the age of 1 year who
receive the rotavirus
vaccine. The medical records of all those who
received the vaccine and
those who did not receive the vaccine over a 6-month
period are
reviewed. Results show 125 cases per 100,000
infant-years for infants who
received the vaccine compared to 45 cases per 100,000
infant-years for
infants who did not receive the vaccine. The
investigators conclude that
the relative risk for intussusception is 1.9 times
greater in infants
who receive the rotavirus vaccine (95% confidence
interval of 0.5“7.7 and
p=0.39). Which of the following is the most accurate
interpretation of
these results?
A
) The results do not show an association between
rotavirus vaccine
and intussusception, but they may be related
B
) The results show sufficient statistical power to
identify an
association between rotavirus vaccine and
intussusception
C
) Rotavirus vaccine is associated with a 39% risk
for
intussusception
D
) Rotavirus vaccine causes intussusception in 1.9%
of infants
E
) Rotavirus vaccine prevents 80 cases of
intussusception per 100,000
infant-years