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A 78-year-old female with a past medical history remarkable for ischemic cardiomyopathy, chronic atrial fibrillation, and diabetes is admitted to the hospital with Escherichia coli urosepsis. She is started on intravenous antibiotics. The course is unremarkable except for the development of delirium. The day of discharge she develops syncope, and she is found to be in polymorphic ventricular tachycardia. Which drug is the least likely to have caused this arrhythmia?
A. Clarithromycin
B. Haloperidol
C. Levofloxacin
D. Olanzapine
E. Sotalol
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Olanzapine is teh answer
rest all either cause QT prolongation or hypokalemia
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DDD is the answer
sorry, I didn't read the question careful. " least"
of course Olanzapine
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The answer is D.
Several drugs are associated with QT interval prolongation and the development of
polymorphic ventricular tachycardia (torsades de pointes). They include antiarrhythmic
agents (quinidine, sotalol, ibutilide, procainamide, amiodarone), antiinfective agents
(quinolones, erythromycin, clarithromycin, pentamidine), antiemetics (droperidol,
domperidone), antipsychotics (haloperidol, thioridazine), and other drugs (cisapride,
methadone). Prologation of the QT interval to more than 500 ms should prompt
consideration of drug alternatives. Unlike other antipsychotic medications, olanzapine
does not contribute significantly to QT prolongation, although caution is recommended
during concomitant treatment with drugs that do prolong the QT interval
