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The oxygen carrier of muscle is the globular protein myoglobin. Which one of the following amino acids is highly likely to be localized within the interior of the molecule?
Options:
1. Arginine
2. Aspartic acid
3. Glutamic acid
4. Valine
5. Lysine
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The Correct Answer is: Valine
Explanation:
The structure of myoglobin is illustrative of most water-soluble proteins. Globular proteins tend to fold into compact configurations with nonpolar cores. The interior of myoglobin is composed almost exclusively of nonpolar, hydrophobic amino acids like valine, leucine, phenylalanine, and methionine. In contrast, polar hydrophilic residues such as arginine, aspartic acid, glutamic acid, and lysine are found mostly on the surface of the water-soluble protein.