direct coombs tes - pacemaker

[ArchivalUser]

wat do we c in
1).warm autoantibody reaction
2).cold antibody reaction
3)drug induced antibody reaction

[ArchivalUser]

2222222

[ArchivalUser]

opps soooooooryy its 11111111111 with IgG

[ArchivalUser]

wat do we c in direct coom's test in different anemias mentioned above OR how is the picture of direct ccombs test in warm,cold n drug induced reactions..
(Or it can also be mentioned itn the other way)
wat information does direct coombs test convey in warm,cold,n drug induced reactions.

[ArchivalUser]

ok
so direct coombs test is for IgG Abs, seen in drug induced and auto-immune hemolytic anemia.
indirect is for anti-RBC Abs..............

[ArchivalUser]

cold Ab reaction= direct coombs test +ve for complement but not for IgG.

in warm Ab anemia ,direct coombs test +ve for IgG n occassionaly cause complement activation.

in drug induced reacion, IgG +ve with no hemolysis,n complement activation.