03-10-2008, 04:03 PM
A 3-month-old boy presents with poor feeding and growth, low muscle tone (hypotonia), elevation of blood lactic acid (lactic acidemia), and mild acidosis (blood pH 7.3 to 7.35). The ratio of pyruvate to lactate in serum is elevated, and there is decreased conversion of pyruvate to acetyl coenzyme A in fibroblasts. Which of the following compounds might be considered for therapy?
A. Pyridoxine
B. Thiamine
C. Free fatty acids
D. Biotin
E. Ascorbic acid
A. Pyridoxine
B. Thiamine
C. Free fatty acids
D. Biotin
E. Ascorbic acid