q2 - 2confused2bdoctor

[ArchivalUser]

15 yr. old girl has had increasing lethargy folowing a bout of the "flu" 3 weeks ago. On physical examination there are no abnormal finding. Her condition does not improve after 3 weeks on corticosteroid therapy, so a renal biopsy is performed. Microscopic examination shows segmental sclerosis of 3 of 10 glomeruli identified in the biopsy specimen. Immunofluorescence studies and electron microscopy do not show immune deposits. What is the most appropr. advice to give the girl's parents regarding her condition?
A She may require a renal transplant in 10 years
B She will probably improve with additional corticosteroid therapy
C She will likely develop a restrictive lung disease
D She has an underlying malignancy
E She will improve if she loses weight

[ArchivalUser]

aa

[ArchivalUser]

A typical course runs from edema that is difficult to manage to proteinuria refractory to corticosteroids and other immunosuppressive agents to worsening hypertension and progressive loss of renal function. so i think ANS: A

[ArchivalUser]

agree a,

[ArchivalUser]

this seems FSGS ee is possible

[ArchivalUser]

Yes its AAA..the findings point to focal segmental glomerulosclerosis (FSGS), which leads to chronic renal failure in half of cases. The lack of resolution with corticosteroid therapy and the progression to chronic renal failure is what sets FSGS apart from minimal change disease.