pharm question 10 - pepsi00

[ArchivalUser]

You want to maintain an average plasma drug concetration of 10 mg/liter.If you were to give the drug by constant intravenous infusion,what would the infusion rate be?

A. 0.19 mg/hr
B. 1.4 mg/hr
C. 0.38 mg/hr
D. 23 mg/hr
E. 45 mg/hr
F. 57 mh/hr
G. cannot determine from the information provided

[ArchivalUser]

Infusion rate = clearance x plasma drug concentration

assuming normal clearance for a man is equal to 100-140 ml/min and a constant infusion rate, then:

infusion rate = 0.14 x 10 = 1.4 mg/hr

So, my best guess will be B)

[ArchivalUser]

so Pepsi00, what's the answer??

BTW, I have a way of remembering that pepsin cleaves the hinge region in the IgG, thus cleaving Fab and Fc portions, where Fab looks like a cup or glass, where you pour pepsi-cola in it.

[ArchivalUser]

lol neuro,good stuff of remembering pepsin.Wasn't there something else that cleaves IgG.
The answer to this question is G.

Because how can you assume his clearance like that?

[ArchivalUser]

LOL, I did it using creatinine clearance. but looking the formula and its elements, I guesss you are right.