Conceptual Q 1 - irfanmir

[ArchivalUser]

64 yrs old male present to ER with right upper quadrant pain. examination was obvious for alcoholic hepatitis which was later confirm with LFT and enz essay. resident no duty start explaining the biochemical aspect of liver damage, than he ask which of the following substrate is most responsibe for increased synthesis of VLDL in hepatocyte in fatty liver.

A lactate
B pyruvate
C Glucose 6 phosphate
D Glycerol 3 phosphate
E phosphoenol pyruvate
F Acetaaldehyde dehydrogenase

[ArchivalUser]

com on guys what hap

[ArchivalUser]

In the hepatocytes, glucose is converted to DHAP, which subsequently is converted to glycerol 3-P.
With the additon of three fatty CoAs, G3-P is coverted to make triglyceride, which is the main content of VLDL excluding some cholesterol.

So, the answer among yr choices is Glycerol 3 phosphate.

[ArchivalUser]

dd

[ArchivalUser]

Good guys right ans is D