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prolactin enhances testosterone function and spermatogenesis.
but in prolactinoma- in men it causes loss of libido due to dec in testosterone.
Iam confused why it is different? I know inc prolactin inhibits GnRH so LH decreases so testosterone decreases.
So it would be because of too much inc in prolactin.
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prolactin enhances testosterone function and spermatogenesis??
can u cite the source?
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Its GOLJAN RAPID REVIEW SECOND EDITION page # 443( male reproductive system)
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Page 443
3. Prolactin
a. Prolactin enhances testosterone function and spermatogenesis.
A number of articles discuss the important role that prolactin normally has in promoting the function of the testis and accessory structures. Prolactin receptors are present in the Leydig cells, differentiating germ cells in the seminiferous tubules, and all of the accessory structures. Specifically, in the Leydig cells, prolactin is important in inducing and maintaining LH receptors; which enhances testosterone function. It also directly has an effect on enhancing spermatogenesis. When prolactin is increased, it shuts off GnRH; which, in turn, decreases testosterone production (LH effect) and spermatogenesis (FSH) effect.
source:
ERRATAS AND CLARIFICATION, there is a list of corrections for RRP, 2ed edition
you can find the list of correction from Dr. Goljan Web site.
