lipoprotein lipase vs harmone sensitive lipase..? - drtilakpasala

[ArchivalUser]

can anybody enlighten me about these two enzymes...

regards....

[ArchivalUser]

Lipoprotein lipase takes triglyceride from blood just after a meal and stores it in adipose tissue
HSL sends TGL out of the adipose, as fatty acid and glycerol, to the liver in fasting states

[ArchivalUser]

1st lipoprotein lipase one is EXTRACELLUAR--which with insulin speed up TG uptake from blood by adipose. A.K.A TG clearing factor lipase.

2nd is hormone sensitive lipase THE INTRACELLULAR ONE--which with stress hormones stimulate lipolysis and with insulin inhibit lipolysis.
Plz correct me if im wrong..

[ArchivalUser]

for the 2nd, it seems lack of insulin plays more important role in promoting lipolyisis, that's the reason in type 1 DM, lot's of FFA produce ketones...

[ArchivalUser]

yes JF in absence of insulin,there wud be lipolysis as insulin is anbolic,DM1 is one condition but also stress hormones,like cortisol,epi,gh,glucagon do actiavte this hormone sensitive liapse and cause lipolysis.

[ArchivalUser]

for drtilakpasala,

lipoprotein lipase is to generate triglycerade.

hormone-sensitive lipase is to decrese triglycerate.

the consequence for DM1, coz insulin is low, 1) lipoprotein liapse activity low...2) hormone sensitive lipase activity is high: triglycerade is used, but not continued provided by lipoprotein.

not sure is this the reason that person with DM1 is not fat..

correct me shiney and others

[ArchivalUser]

to juneflower,
dear, u r right, I feel your MS in Bio!!!!!
Good luck

[ArchivalUser]

hey...thanks...for clearing things up...

this is better than google....

i tried finding this on google with out much success

regards