09-02-2008, 01:25 PM
hahaha
my first choice was correct ..(never look back)
thanks
my first choice was correct ..(never look back)
thanks
genetic question.. - upinthesky
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09-02-2008, 01:25 PM
hahaha
my first choice was correct ..(never look back) thanks
09-02-2008, 07:34 PM
well, that was a question that i wrote... but i'm going through it again, and i found that it's not 100% accurate... and here's what i wanna say:
EVERYBODY that is exposed to UV light is gonna be prone for developing T=T dimers... BUT in pts with xeroderma pigmentosum, the MUTATION is in the DNA repair system that should ( in normal individuals) excise that T=T dimer, and repair the defect, but since there's a genetic defect involving the gene of the enxyme responsible for that which is ( the enzyme) part of the nucleotide excision repair system (NER), the repair would not happen.... sooo.. making long story short: the MUTATION is in the NER system... the mechanism of UV DNA distortion, is pyrimidines dimerization... so getting back to the question, i guess there should be another choice: mutation in NER DNA repair system... since the quest is about what is the type of DNA mutation.. sorry guys for that....
09-02-2008, 07:50 PM
yes, hey Upin,
I also cheked Lippincot Biochemistry , i did not know that this Q was created by u, whatever, it was a good try and good review, thanks, |
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