NBME2 Block1 Q43 - ritonavir

[ArchivalUser]

A 52-year-old woman, gravida 3, para 3, comes
to the physician
because of irregular vaginal bleeding over the past 2
months. She has
hypertension treated with enalapril and type 2
diabetes mellitus well
controlled with diet. Menopause occurred 2 years ago.
Her maternal aunt
had breast cancer at the age of 70 years. The patient
weighs 88 kg
(195 lb) and is 160 cm (63 in) tall. Examination
shows no other
abnormalities. An endometrial biopsy specimen shows
adenocarcinoma. Which of
the following is the most significant predisposing
factor for this
patient's endometrial cancer?

A
) Heredity

B
) Hypertension

C
) Parity

D
) Type 2 diabetes mellitus

E
) Weight

[ArchivalUser]

E..

[ArchivalUser]

eee

[ArchivalUser]

What is the reason for weight.?
Is that because of excess adopose tissue estrogen production?
Because the etiology for endometrial cancer is Estrogen.....

[ArchivalUser]

E.
excess adipose tissue responsible for high estrogen.

[ArchivalUser]

Obesity is rated differently according to overweight excess:
- 21-50 lbs relative risk is 2-4
- >50 lbs relative risk is 10

DM type 2 relative risk is 2-8