08-08-2009, 08:10 AM
can any kind soul can explain how oral contraceptives cause hepatoceullar ca?
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hepatocelluar ca and ocps? - cindrella
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08-08-2009, 03:30 PM
The long-term use of oral contraceptives is associated with the development of hepatic adenomas (benign tumor) not carcinomas. the reason is probaly the increase in estrogens. dont know more details.
08-08-2009, 03:33 PM
estrogens contribute to HCC development primarily through mitogen stimulation ( p53 mutation )and secondarliy by mutagenesis via hydroxyl radicals produced during estrogen metabolism.
08-08-2009, 09:20 PM
thanks alot masha
..its given in goljan neoplasia topic in section of chemical carcinigens. i serached the wikipedia but didnt get the answer... thanka again all of you for ur valuable time n input
08-08-2009, 09:39 PM
your welcome, actually your question was like a ring a bell and made me to google it. the concept i got is from an article ...........
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