nbme 2 q - sara21

[ArchivalUser]

1. Tumor necrosis factor is the primary mediator of host responses initiated by lipopolysaccharide (LPS) and
leading to septic shock. LPS-mediated activation of transcription most likely depends on which of the following
transcription factors?
O A) o-res
o B) Nuclear factor-kappa B
OC) p53
0 0 ) Rb protein
o E) VP-16 (etoposide)
"
can u explain the answer?

[ArchivalUser]

"b"
LPS binds to LPS receptor on the macrophages (CD14)
this activates macrophages, n via the actiavtion of transcription factor NFKB, it wd release TNF-a

[ArchivalUser]

many thx