tss - yunamd

[ArchivalUser]

Toxic shock syndrome toxin-1 is produced by some strains of S. aureus and is thought to be responsible for the clinical manifestations of disease by this organism. This toxin is referred to as a superantigen because it can
a. Activate T cells in an antigen-nonspecific manner
b. Activate B cells without T cell help
c. Become immunogenic when attached to a carrier protein
d. Prolong the presence of antigen in a tissue
e. Evoke IgE

[ArchivalUser]

a. activate T cells in an antigen-nonspecific manner ??

[ArchivalUser]

a
superantigen binds outside Ag-binding cleft -> crosslink B domain of T-cell to alpha chain of MHC class II -> polyclonal activation of T cells

[ArchivalUser]

AA

[ArchivalUser]

absolutely correct.
A