NBME 5 Question - myusmlestep

[ArchivalUser]

Prostacylin (PGI2) synthesized by endothelial cells promotes which of the following?

A. Adhesion of Platelets
B. Expression of selectins
C. Priming of leukocytes
D. Production of Nitric oxide
E. Vasodilation



I'm confused between D and E. Please give me the correct ans

[ArchivalUser]

E. PGI2 binds to endothelial prostacyclin receptors(G-protein linked receptor) and raises cAMP levels in the cytosol. This cAMP then goes on to activate protein kinase A (PKA). PKA then continues the cascade by phosphorylating and inhibiting myosin light-chain kinase which leads to smooth muscle relaxation and vasodilation.

[ArchivalUser]

ee is correct

[ArchivalUser]

EE

[ArchivalUser]

IT IS E `100 %
PGI2 IT HAS NOTHING TO DO WITH NO

[ArchivalUser]

it is E