Lab findings - sunshine2009

[ArchivalUser]

A 15 month old girl is brought to the Doc. because of a 6 month history of progressive weakness and fatigue. Examination shows tachycardia, scleral icterus, pallor, hepatosplenomegaly. Her Hb conc. is 5.6 g/dl (N=11.5-14.5) and serum indirect Bili 3 mg/dl//

A peripheral blood smear shows severe hypochromia, nucleated Erys, microcytosis ..DNA analysis shows an A--->G point mutation within the TATA box of the B globulin ..

What is the lab in this patient:

Hb F increased
HbA2/Hb A Ratio Increased
Reti Increased

Anyone can please explain the lab findings

[ArchivalUser]

i think its a case of B thalasemia ...HbA2/HbA ratio is increased

[ArchivalUser]

Hb F is increased and retis are increased I do understand this.But what presents again HbA2/Hb A ratio and why increased in a child?

[ArchivalUser]

HbA2 consists of tow alpha and two segma chains...while hb A consits of two alpha and two beta chains...in beta thalasemia beta chain are unable to formed so HbA decreases....
Hbf AND HbA2 increases