02-18-2010, 11:05 AM
the role of DNA Topoisomerase 1 in DNA replication. pls explain
biochem - tjkasante
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02-18-2010, 11:05 AM
the role of DNA Topoisomerase 1 in DNA replication. pls explain
02-18-2010, 11:38 AM
introduces negative supercoils in a single DNA strand..
topoisomerase II does tht with both the strands at the same time inhibited by etoposide (anti-cancer) and quinolones (anti bacterial ) am not sure which one is for wht
02-18-2010, 11:54 AM
dna gyrase (topoisomerase II) introduce the negative supercoiling by cutting both strands and resealing
dna topoisomerase I can relax the supercoil, by cutting and resealing one strand Quinolones inhibits dna topoisomerase II in prokaryotes Etoposide, teniposide inhibits dna topoisomerase II in eukaryotes That's my understanding; if I am wrong please correct me. |
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