08-05-2005, 09:56 AM
hi,
the answer is C.
OBJ: HEMORRHAGIC BULLAE CHARECTERISE THE ACUTE SKIN MANIFESTATION IN AN SLE FLARE.
SLE is systemic multiorgan disease that involves connective tissue and blood vessels. Fever and skin lesions are the most common manifestations, while arthritis and renal pulm disease are also common. The charecteristic rash, as exemplified by the patient in this question is an erythematous ,confluent,macular eruption in a butterfly pattern on the face and arms, "hemorrhagic bullae" during acute flares,and discoid plaques, which would typify chronic discoid lupus erythematosis. Vasculitis of lupus also presents with purpura. Skin biopsy reveals an atrophic epidermis with liquefaction necrosis at the dermal-epidermal junction,edema of dermis, and a lymphocytic infiltrate. Fibrinoid degeneration of teh connective tissue and blood vessel wall may also be noted. I.F. studies demonstarte staining for Ig in a granular or globular pattern along the dermal-epidermal junction.
the answer is C.
OBJ: HEMORRHAGIC BULLAE CHARECTERISE THE ACUTE SKIN MANIFESTATION IN AN SLE FLARE.
SLE is systemic multiorgan disease that involves connective tissue and blood vessels. Fever and skin lesions are the most common manifestations, while arthritis and renal pulm disease are also common. The charecteristic rash, as exemplified by the patient in this question is an erythematous ,confluent,macular eruption in a butterfly pattern on the face and arms, "hemorrhagic bullae" during acute flares,and discoid plaques, which would typify chronic discoid lupus erythematosis. Vasculitis of lupus also presents with purpura. Skin biopsy reveals an atrophic epidermis with liquefaction necrosis at the dermal-epidermal junction,edema of dermis, and a lymphocytic infiltrate. Fibrinoid degeneration of teh connective tissue and blood vessel wall may also be noted. I.F. studies demonstarte staining for Ig in a granular or globular pattern along the dermal-epidermal junction.