07-15-2010, 11:15 PM
does TMP-SMX have any effect on cytochrome p450 ...??
doubt ? - spring09
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07-15-2010, 11:15 PM
does TMP-SMX have any effect on cytochrome p450 ...??
07-15-2010, 11:52 PM
Sulphamethoxazole is extensively metabolized in vivo; its metabolic pathways involve acetylation, oxidation and glucuronidation
Oxidation takes place at different positions of the molecule: the unstable, reactive hydroxylamine metabolite is formed by oxidation of the N4 nitrogen atom while oxidation of the C5 methyl group leads to the stable 5-hydroxy metabolite. Formation of both metabolites by cytochrome P450-mediated reaction was demonstrated in vitro using human liver microsomes. In vitro more sulphamethoxazole was N-hydroxylated than 5-hydroxylated. You can follow this link... to see how deep they can go with it ![]() http://jac.oxfordjournals.org/cgi/reprin...l_B/55.pdf Good Luck ![]()
07-15-2010, 11:53 PM
Sulphamethoxazole is extensively metabolized in vivo; its metabolic pathways involve acetylation, oxidation and glucuronidation
Oxidation takes place at different positions of the molecule: the unstable, reactive hydroxylamine metabolite is formed by oxidation of the N4 nitrogen atom while oxidation of the C5 methyl group leads to the stable 5-hydroxy metabolite. Formation of both metabolites by cytochrome P450-mediated reaction was demonstrated in vitro using human liver microsomes. In vitro more sulphamethoxazole was N-hydroxylated than 5-hydroxylated. You can follow this link... to see how deep they can go with it ![]() http://jac.oxfordjournals.org/cgi/reprin...l_B/55.pdf Good Luck ![]()
07-16-2010, 04:45 AM
Hi spring09
TMP-SMX may act as an inhibitor of P450, thereby increasing the levels, and possibly toxicity, of other substrates, e.g. phenytoin. Hope you're doing well ![]()
07-16-2010, 04:52 AM
thanks !!
so if a pt. is on warfarin , and tmp-smx , we decrease the dose of warfarin ..right .. it's in the fred exam .
07-16-2010, 05:07 AM
Affirmative, as far as I am concerned
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