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q6 - honey91
#1
A 40-year-old female with a history of AIDS develops a herpes simplex
keratitis of the eye. Which of the following antiviral agents should be administered in this case

a. Zanamivir

b. Trifluridine

c. Zidovudine

d. Amantadine

e. Indinavir
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#2
bb
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#3
BB.
hi medipro Smile
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#4
Hi psychmle !
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#5
bbbbb
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#6
what is the mechanism?
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#7
trifluridinne is a topical antiviral ophthalmic preparation used specifically for viral keratoconjunctivitis especially herpes simplex keratitis.
It is not indicated for herpes zoster induced kearatitis!
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#8
answer is B.

Trifluridine inhibits viral activity in HSV types 1 and 2, CMV, vaccinia, and perhaps adenovirus. It acts as a viral DNA synthesis inhibitor by irreversibly blocking thymidylate synthetase.

Trifluridine triphosphate is a competitive inhibitor of thymidine
triphosphate accumulation into DNA.

It is used in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis caused by HSV 1 and 2.

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