q6 - honey91

[ArchivalUser]

A 40-year-old female with a history of AIDS develops a herpes simplex
keratitis of the eye. Which of the following antiviral agents should be administered in this case

a. Zanamivir

b. Trifluridine

c. Zidovudine

d. Amantadine

e. Indinavir

[ArchivalUser]

bb

[ArchivalUser]

BB.
hi medipro

[ArchivalUser]

Hi psychmle !

[ArchivalUser]

bbbbb

[ArchivalUser]

what is the mechanism?

[ArchivalUser]

trifluridinne is a topical antiviral ophthalmic preparation used specifically for viral keratoconjunctivitis especially herpes simplex keratitis.
It is not indicated for herpes zoster induced kearatitis!

[ArchivalUser]

answer is B.

Trifluridine inhibits viral activity in HSV types 1 and 2, CMV, vaccinia, and perhaps adenovirus. It acts as a viral DNA synthesis inhibitor by irreversibly blocking thymidylate synthetase.

Trifluridine triphosphate is a competitive inhibitor of thymidine
triphosphate accumulation into DNA.

It is used in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis caused by HSV 1 and 2.