the bacteria that causes a condition - usmle360

[ArchivalUser]

where the patient develops an acute inflammatory polyneurophaty has this mechanism of action?

[ArchivalUser]

Campylobacter jejuni, GB- syndrome

[ArchivalUser]

yes, but the MOA is?

[ArchivalUser]

antigenic mimicking{ bacterial antigenic structure closely resembles human tissues} so our anti bodies cross react against our own tissues. kindly correct me if i am wrong

[ArchivalUser]

Inflammation and demyelination of peripheral nerves and motor fibres of ventral roots, causing symmetric ascending muscle weakness beginning in the lower limbs.

Lab findings in CSF??

[ArchivalUser]

peripheral demyelinating disease..self destruction of mylein sheath by T cells.... in peripheral nerves just like in MS....Type IV hypersensitivity....

[ArchivalUser]

albumino cytologic dissociation in CSF...normal no of cells...high albumin...

[ArchivalUser]

the moa of Campylobacter(enterotoxin) is simply activating the adenylate cyclase.G.Barre is a serious disorder that occurs when the body's defense (immune) system mistakenly attacks part of the nervous system. This leads to nerve inflammation that causes muscle weakness.