can anyone explain allelic exclusion - amulya

[ArchivalUser]

and somatic hypermutation in simple words

[ArchivalUser]

*rearrangment alleles are 2 each one on either arm of chromosome...they encode rerrang.
which determine specifity of idiotype toward specific Ag ,,,IF..this process done by
one allele ..the another one not need any more and subjected to exclusion
*somatic hypermutation is componsatory mechanisim coz of loss of AVIDITY of IgM due to switching to scondary immune respone,, the cell try to inc. immune affinity by mutation at variable regeion which encode idiotype of Ig and one with highest affenity for binding Ag will be predominante for long time=clonal selection