Immunology Q - maryam2009

[ArchivalUser]

How Arthus (III) and delayed cell mediated (IV) reactions can be diffrentiated phentypically?...just with immunoflurecent staining (visualize Antigen-antibody comlex)? please post some examples of Arthus reactions.Thank you in advance

[ArchivalUser]

Arthus reactions :

It is a rare, severe, immediate nonatopic hypersensitivity reaction to the injection of a foreign substance, that usually is not irritating but in certain individuals is antigenic. The reaction is thought to involve the formation of an antigen-antibody complex that activates complement. Acute local inflammation, usually in the skin and marked by edema, hemorrhage, and necrosis, occurs at the site of injection.

Arthus reactions have been infrequently reported after vaccination against diphtheria and tetanus.

http://www.dermis.net/dermisroot/en/24404/image.htm

Delayed hypersensitivity reactions are inflammatory reactions initiated by mononuclear leukocytes.These reactions are mediated by T cells and monocytes/macrophages rather than by antibodies.

http://coursewareobjects.elsevier.com/ob...l0128.html