Ryanodine receptor - savi

[ArchivalUser]

what is it?

[ArchivalUser]

source:website
The ryanodine receptor (RyR) releases calcium ions from the sarcoplasmic /endoplasmic reticulum (SR/ER) into the cytosol and thereby converts extracellular stimuli into intracellular calcium signals or amplifies and regulates the intracellular calcium concentration. RyRs are found in most cell types but they are concentrated in striated muscle; they are crucial components of the cascade leading to muscle contraction. The contraction of striated muscle cells is initiated by the release of SR Ca2+ via RyR. In cardiac muscle RyR2 is believed to open is response to an influx of Ca2+ to the cell via dihydropyridine-sensitive Ca+ channels in the cell surface membrane; a process referred to as Ca2+ induced Ca2+ release. In skeletal muscle cells the opening of RyR1 appears to be mediated by a direct coupling of RyR to the dihydropyridine-sensitive Ca2+ channel.

[ArchivalUser]

thanks,step1mom.

[ArchivalUser]

np

[ArchivalUser]

Also note that mutation in ryanodine receptor in SR lis the cause of maliganant hyperthermia, where there is uncontrlled release of ca2+

[ArchivalUser]

thanks hkv.

I found some more information.Along with malignant hyperthermia,mutations inRyR leads to central core disease of muscle.But i don`t know what kind of the disease it is.
Also there are 3 types:
RyR1-found in sk.muscle
RyR2-in heart muscle
RyR3-in brain.