why is there hypokalemia in diabeties insipidus - 1128

[ArchivalUser]

hypokalemia in nephorgenic diabeties insipidus....why? please explain

[ArchivalUser]

because of increased urine flow rate

[ArchivalUser]

one of the consequences of hypokalemia is diabeties insipidus.....how can hypokalemia cause diabeties Insp?

[ArchivalUser]

Hypokalemia REDUCES the expression of aquaporin channel-2 in the same way as lithium would.....

ADH INCREASES the expression of this channel...

thus hypokalemia and lithium cause Nephrogenic diabetes Insipidus.... (DI does not cause hypokalemia...its the other way around)

Reference : http://www.springerlink.com/content/e2d0bakdf9l5ktc8/

[ArchivalUser]

Central DI and Nephrogenic DI cause hypokalemia (with increased urine flow rate ) as CHRONIC hypokalemia cause NDI (not CDI ) due to resistance in AQ channels .

[ArchivalUser]

thank you thank you!!!!!!!!!!!!!!!!!!!!!!!!!!

[ArchivalUser]

hmmmm... @mlenailer....you might be right...but i didnt come across it...

thanks anyway