Biochem question Uw - prusmle

[ArchivalUser]

14 y/o male is being evaluated for splenomegaly. Enzyme essays on blood cells demostrate low pyruvate kinase activity. Wich of the follwing is the most llikely cause of this patient's splenomegaly?

a-intracell. subst. accumulation
b-Passive congestion
c-Inflammatory infiltration
d-Work hypertrophy
e-Neoplastic lesion

[ArchivalUser]

D....

[ArchivalUser]

DD

[ArchivalUser]

Yes it is DDD... Pyruvate kinase deficiency produce red blood cell structure abnormalities due to lack of ATP production in glycolysis; due to lot of work of spleen destroying the RBC's becomes hypertrophied.
Any other info, please add....