itp - blood

[ArchivalUser]

Is ITP has splenomegally?

I understand if steriod fails you will do splenectomy? right?

Thanks

[ArchivalUser]

No, ITP itself doesn't develop spleenomegally. It's a very important diferentiating point from other reasons of thrombocytopenia.

Reason behind spleenectomy of rx unresponed case:
Immune destruction of platelets ( platelets- antibody complex is engulfed by macrophage in the spleen) is happened in spleen. So if patient doesn't have spleen, there will be no place to platelets destruction!

Hope it helps.