Why a high BUN & normal CR in Upper GI Bleed? - apple09

[ArchivalUser]

Why does a high BUN and normal creatinine suggest an Upper GI hemorrhage/bleed?

[ArchivalUser]

B/c intestinal bacteria acts on the blood proteins to form nitrogen which is absorbed there4 raising BUN without affecting creatinine which can rise in conditions like renal failure,rhabdomyolysis.

[ArchivalUser]

I think other factors that influence it also, such as the fact that youre bleeding and the first organ that is usually affected is of course KIDNEYS

[ArchivalUser]

because bleeding results to a prerenal type renal damage wherein bun rises more than crea, hence bun crea ratio greater than 20 usually