q.2_____________? - sarim

[ArchivalUser]

http://www.bmrb.wisc.edu/metabolomics/st...t/3596.png

In the above amino acid we introduce a group to produce the following

http://www.ebi.ac.uk/pdbe-apps/widgets/Q...cs/CGU.gif



Q-This amino acid modification is done for which proteins, in order for them to function?

[ArchivalUser]

Is it gamma-carboxylation(addition of HOOC)? or a hydroxylation rxn?

[ArchivalUser]

I am thinking of hydroxylation reactions.............>hydroxylation of lysine in collagen synthesis?

[ArchivalUser]

right

First slide: Amino acid "Glutamate"

Addition of "Carboxyl group"(COOH) by the process called "Gamma-Carboxylation"

to produce
Second slide: "Carboxyglutamic acid"


*A Post-translation Modification needed for "Vit-k dependent Clotting Factors"(II, VII, IX, X, protein C and S)

*This modification Increases the affinity for "Calcium Attachment" to the carboxyglutamic acid residue , which is essential for the activity of these proteins.

[ArchivalUser]

Thank you so much Sarim,short of words.samideb