qbank:block10:q14 - hallucination

[ArchivalUser]

14>A 47-year-old woman presents with complaints of nervousness and
increased sensitivity to hot weather. She is diagnosed with hyperthyroidism
and prescribed propylthiouracil. What is the principal mechanism by which
this drug acts?
A. Decreasing the efficacy of TSH binding to the thyroid TSH receptor
B. Decreasing the rate of proteolysis of thyroglobulin
C. Increasing the amount of 3,3',5'-triiodothyronine (reverse T3; rT3)
D. Inhibiting deiodination of thyroxine (T4)
E. Inhibiting the uptake of iodide into the thyroid gland

[ArchivalUser]

D. Inhibiting deiodination of thyroxine (T4)

[ArchivalUser]

it is not E.I wonder why the explaination says its E.I agree with D too.

[ArchivalUser]

I am sure it is D. By inhibiting thyroid peroxidase, also by inhibiting peripheral conversion of T4 to T3. This is very important. I did two forms of NBME, each one contains at least one MOA of antithyroid drugs. I got one on my real exam too, directly from NBME.

[ArchivalUser]

yeah.I also believe that.