patho q 2 - ebv

[ArchivalUser]

larvae of trichenella spiralis are present within the skeletal muscle fibres of the diaphragm of a 23 year old male. he has fever and peripheral blood eosinophilia. years later chest radiograph showed a few small calcifications in the diaphragm. which of the following immunological mechanisms contributed to the destruction of the larave?
a> ADCC
b> complement mediated cell lysis
c> formation of langerhans cells
d>abcess formation wit neutrophils
e> synthesis of leukotrien c4 inmast cells

[ArchivalUser]

a?

[ArchivalUser]

correct!

[ArchivalUser]

i didnt get u,can u plz explain?

[ArchivalUser]

please explain

[ArchivalUser]

This is a type II hypersensitivity. Antibody dependent cellular cytotocity. ADCC may be mediated by monocyte, neutrophils and eosinophils and NK cells.
In paratites infection, in addition to IgG, IgE antibodies are also used.

[ArchivalUser]

this is an eg of ab dependent cell mediate cytotoxicity mediated directed at a parsitic inf. IgG and IgE ab bearing Fc receptors coat the parasite. Macrophages, NK cells and neutrophils can recognise the Fc receptor and lyse the Ab coated target cells