FA immuno confused... - 3usmlesteps

[ArchivalUser]

It says that Th cells are not involved, but yet they say MHC 2 on APC binds to T cell. And it can't be CD 8 T cell as that uses MHC 1. So are they talking about the regulatory T cell?
What do they mean by **Th cells are not involved**?



--------------------------------FA immuno

Effects of bacterial toxins
Superantigens (S. pyogenes and S. aureus)—cross-link the β region of the T-cell receptor to the
MHC class II on APCs. Can activate any T cell, leading to massive release of cytokines.
Endotoxins/lipopolysaccharide (gram-negative bacteria)—directly stimulate macrophages by
binding to endotoxin receptor CD14; Th cells are not involved.

[ArchivalUser]

I believe it's discussing 1) the superantigen (gram + Staph. and Strep.), then 2) the endotoxin (gram - bacteria). Two separate issues.