question 5 - usmledreamz

[ArchivalUser]

A 24-year-old man is seen in the clinic with multiple large nevi with irregular pigmentation. Excisional biopsy of several of the lesions shows similar features, with cytologic and architectural atypia. The pathologist did not consider any of the lesions he examined severe enough to warrant a diagnosis of melanoma. This patient's condition is associated with which of the following?

A. Birbeck granules
B. CMM1 gene
C. Desmoglein 3
D. Leser-Trélat sign
E. Munro microabscesses

[ArchivalUser]

DD

[ArchivalUser]

dd

[ArchivalUser]

can anyone explain please

[ArchivalUser]

The correct answer is B. This patient has dysplastic nevus syndrome, which is an autosomal dominant condition related in many affected families to the CMM1 gene on chromosome 1.

Associate the other answers with the following diseases: Birbeck granules, histiocytosis X; desmoglein 3, pemphigus; Leser-Trélat sign, seborrheic keratoses; Munro microabscesses, psoriasis.