Question..........................3 - psychmledr

[ArchivalUser]

A 4-year-old boy is brought to you because of easy bruising. P/E reveals soft and loose skin as well as multiple ecchymoses on the forearm and pretibial regions. Histological evaluation shows abnormally thin and irregular type 1 collagen fibrils. Biochemical evaluation reveals presence of disulfide-rich globular domains within a purified sample of mature collagen fibrils. Which of the following stages of collagen synthesis is most likely impaired in this patient?

A. Amino acid incorporation into proteins
B. Extracellular protein cleavage
C. Lysine residue hydroxylation
D. Signal peptide recognition
E. Triple helix formation

[ArchivalUser]

B.
thank u.

[ArchivalUser]

b

[ArchivalUser]

Q. Which part of collagen synthesis is affected here?

[ArchivalUser]

B is the reasonable ans ....

The ability of macrophages and other cells to mobilize elastolytic cysteine proteases to their surfaces under specialized conditions lead to accelerated collagen and elastin degradation at sites of inflammation in diseases such as atherosclerosis and emphysema.

[ArchivalUser]

B. ty

[ArchivalUser]

BB

After exocytosis of procollagen i.e, when it is outside fibroblast. The terminal region is cleaved to transform procollagen into tropocollagen (insoluble).

Thanks for the Q

[ArchivalUser]

Thanks for the questions.

[ArchivalUser]

"B" is right as explained. Thanks.

You are very welcome