@freshmind1 - cardio69

[ArchivalUser]

NOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

ans *C*

Carvedilol is NOT cardioselective IS a NON-selective beta-blocker W alfa 1-blocking activity

DO U UNDERSTAND that?

[ArchivalUser]

Oh... I forgot A to M are selective and N to Z BB+Carvedilol/Labetolol are non selective.

[ArchivalUser]

Rt
Hope u don't get offended and for your own good U need to know this basic concept for step 1 not "Carvedilol/Spironolactone to decrease progression of CHF?"

Anyhow, UW is correct spirolactone does it add on ACE to reduce episodes decompensation & death /in low dose use aldosterone antagonist are useful inhibition of cardiac extrasellar matrix & collagen dep -> prevent cardiac fibrosis & V remodeling ( Spirolactone has high affinity for androgen & progesterone R & u know eplerenone has low affinity for these R)

Carvedilol /peripheral vasoDilatin & ↓BP + ↓lipid peroxidation & vascular wall thickening CHF

In all what they do IN BIG PIC? SLOW down tissue remodeling....
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Q) Can u tell me if the pat above CHF base on steam q?

a) Systolic dysfunction
b) Diastolic dysfunction

[ArchivalUser]

Thanks Cardio,

This pt has "decrease EF which decreases EF lead to decease SV" so

A-systolic dysfunction

[ArchivalUser]

RT.


Carvedilol is a substrate of P-glycoprotein/P-gp. ↑ ( not ↓ effects of carvedilol may occur if it coad with P-gp INhibitors.



Welcome.
Happy study!