07-27-2016, 07:49 PM
A 12-year-old girl is brought to the physician because of a 1-year history of progressive facial hair growth and acne. The mother reports that her daughter has grown 4 inches during the past 4 months. Breast development is Tanner stage 1, and axillary and pubic hair development are Tanner stage 3. Physical exam shows dark hair over the upper lip, cheeks and chin. There is acne vulgarism over the cheeks. Pelvic examination shows a 2-cm vaginal canal, significant clitoromegaly, posterior labioscrotal fusion and no cervix or palpable uterus. Abdominal ultrasonography shows bilateral gonads without follicles; there is no uterus. Chromosonal analysis is most likely to show which of the following karyotypes?
A) 45, X
B) 46, XX
C) 46, XY
D) 47, XXY
E) 47, XYY
A) 45, X
B) 46, XX
C) 46, XY
D) 47, XXY
E) 47, XYY