Anything missing w Alcoholic Hepatitis? - goodman

[ArchivalUser]

A.S.T. / A.L.T ratio grater or equal to 2.5 support the Dx. Abdominal pain, nausea, mild jaundice, low-grade fever, malaise.
Example of Eubiquination Process in the Mallory Bodies. The Intermediate Filament damage is KERATIN. Gamma glutamil transfarase is ↑↑
Hypercholesterolemia, also ↑ of Alkaline phosphate, light color stool, and itching.
Acethaldehyde attach w/ protein changing the process to storage Vit A to process to form collagen (fibrosis) = Mechanism that damage the LIVER

ETHANOL METABOLISM
** DISULFIRAN (Antabuse) inhibits acetaldehyde deydrogenase (acetaldehyde accumulates, contributing to hangover symptoms).
** NAD+ is the limiting reagant.
** Alcohol dehydrogenase operates via zero-order kinetics.

[ArchivalUser]

A 46-year-old man visits his physician because he has noted increasing abdominal enlargement over the past 15
months. Physical examination shows several skin lesions on the upper chest that have central pulsatile cores. Pressing on a core causes a radially arranged array of subcutaneous arterioles to blanch. The size of the lesions, from core to periphery, is 0.5 to 1.5 cm. Laboratory studies show serum glucose of 119 mg/dL, creatinine of 1.1 mg/dL, total protein of 5.8 g/dL, and albumin of 3.4 g/dL. Which of the following underlying diseases is most likely to be present in this patient?
(A) Wegener granulomatosis
(B) Micronodular cirrhosis
© Marfan syndrome
(D) AIDS
(E) Diabetes mellitus

[ArchivalUser]

After a heavy bout of drinking over the weekend, a 38-year-old man feels acutely ill with nausea, upper abdominal pain, and jaundice. On physical examination, there is right upper quadrant tenderness. Laboratory studies include a total WBC count of 16,120/mm3 with 82% segmented neutrophils, 8% bands, 8% lymphocytes, and 2% monocytes. The total serum bilirubin is 4.9 mg/dL, AST is 542 U/L, ALT is 550 U/L, and alkaline phosphatase is 118 U/L. A liver biopsy is done; the microscopic appearance of a biopsy specimen shows one or more aggregates of randomly oriented paranuclear eosinophilic microfilaments which stain for cytokeratin, p62 and ubiquitin. Which of the following terms best describes these findings?
(A) Apoptosis
(B) Centrilobular congestion
© Cholestasis
(D) Hemosiderin deposition
(E) Hepatocellular carcinoma
(F) Mallory bodies
(G) Periportal PAS-positive globules