09-11-2017, 09:09 AM
Assoc with HYPOKALEMIA, There is presence of "U" waves in the ECG, also increase "QT" interval and flat "T" waves.
I.V. is Tx of disseminated Histoplasmosis + lifelong Tx with itraconazole
We can use in Cryptococcal Meningoencephalitis in AIDS Pt. w/ headache, vomiting and delirium.
Use in the Tx of Mucormycosis, a devastating fungal infection that is seen in debilitated Pt and in Diabetics. Also we can do a surgical debridant
M. of Action: Binds ergosterol (unique to fungi); forms membrane pores that allow leakage of electrolytes and disrupt homeostasis.
Clinical Use: Used for wide spectrum of systemic mycoses. Cryptococcus, Blastomyces, Coccidioides, Aspergillus, Histoplasma, Candida, Mucor.
Clinical Use: Intrathecally for fungal meningitis; does not cross blood-brain barrier.
Toxicity: Fever/chills ("shake and bake"), hypotension, nephrotoxicity, arrhythmias ("amphoterrible").
I.V. is Tx of disseminated Histoplasmosis + lifelong Tx with itraconazole
We can use in Cryptococcal Meningoencephalitis in AIDS Pt. w/ headache, vomiting and delirium.
Use in the Tx of Mucormycosis, a devastating fungal infection that is seen in debilitated Pt and in Diabetics. Also we can do a surgical debridant
M. of Action: Binds ergosterol (unique to fungi); forms membrane pores that allow leakage of electrolytes and disrupt homeostasis.
Clinical Use: Used for wide spectrum of systemic mycoses. Cryptococcus, Blastomyces, Coccidioides, Aspergillus, Histoplasma, Candida, Mucor.
Clinical Use: Intrathecally for fungal meningitis; does not cross blood-brain barrier.
Toxicity: Fever/chills ("shake and bake"), hypotension, nephrotoxicity, arrhythmias ("amphoterrible").