09-11-2017, 09:30 AM
Can be cause by LONG STANDING RHEUMATIC ARTHRITIS
Skin plaques around axillary folds + macroglossia + hepatosplenomegaly + Pitting edema of the legs + peripheral neuropathy
NSDx Biopsy of skin, rectal mucosa, abdominal fat.
In Echocardiogram reveals ventricular walls with a "speckled pattern".
Amyloid deposits appear similar by light and electron microscopy, but actually represent a heterogeneous population of proteins.
This proteins have common tertiary structure forming a beta-pleated sheet.
Questions about the type of amyloid seen in different disease states (even though the type is usually not determined clinically) are favorites on USMLE
We can see two types of amyloid changes: LOCALIZED and SYSTEMIC.
Skin plaques around axillary folds + macroglossia + hepatosplenomegaly + Pitting edema of the legs + peripheral neuropathy
NSDx Biopsy of skin, rectal mucosa, abdominal fat.
In Echocardiogram reveals ventricular walls with a "speckled pattern".
Amyloid deposits appear similar by light and electron microscopy, but actually represent a heterogeneous population of proteins.
This proteins have common tertiary structure forming a beta-pleated sheet.
Questions about the type of amyloid seen in different disease states (even though the type is usually not determined clinically) are favorites on USMLE
We can see two types of amyloid changes: LOCALIZED and SYSTEMIC.