01-27-2018, 11:24 AM
You need to connect the dots:
TYPE OF ANEMIA
Iron Deficiency
Anemia of Chronic Disease
Sideroblastic Anemia
Thalasemia
SERUM Fe
Low
Low
High
Normal/High
TIBC (TRANSFERRIN)
High
Low
Normal/High
Normal/High
Serum Ferritin
Low
Normal/High
High
Normal/High
Other
* Look for Blood Loss.
* May be Normocytic and Lost of Weight
* Give Pyridoxine (B6) to see if responsive
* Check HbA2, HbF levels.
The CBC and The Reticulocyte Count (T.R.C) can divide the anemias in: T.R.C < 2.5 = R.B.C Morphology Anemias.
T.R.C > 2.5 = Hemolysis/Hemorrhage Anemias
Morphology Anemias we divide according with M.C.V. (Mean Corpuscular Volume): Normal Value 80-100 ųm³.
In that way we can have the following Morphology Anemias: Normocytic Normochromic, Micro or Macrocytic.
Normocytic Normochromic (Hypoproliferative) can be: 1) Marrow Damage: Infiltration/Fibrosis, Aplasia. 2) Iron Deficiency.
3) Decrease Stimulation: Inflammation, Metabolic Defect, Renal Disease.
Micro or Macrocytic Anemias (Maturation Disorder) we have: 1) Cytoplasmic Defects and 2) Nuclear Defects
Cytoplasmic Defects examples are: Iron deficency Anemia, Thalasemias, Sideroblastic Anemia.
Nuclear Defects examples are: Folate Deficiency, Vit B12 deficiency, Drug Toxicity, Refractory Anemia.
Most of Macrocytic Anemias are caused by Processes that interfere with normal DNA synthesis and replication.
Hemolysis/Hemorrhage Anemias = Hemolytic Anemias (T.R.C >2.5). Can have different causes, like: Blood Loss, Intravascular Hemolysis
Another causes of Hemolytic: Metabolic Defect, Membrane Abnormality, Hemoglobinopathy, Autoimmune Defect, Fragmentation Hemolysis
TYPE OF ANEMIA
Iron Deficiency
Anemia of Chronic Disease
Sideroblastic Anemia
Thalasemia
SERUM Fe
Low
Low
High
Normal/High
TIBC (TRANSFERRIN)
High
Low
Normal/High
Normal/High
Serum Ferritin
Low
Normal/High
High
Normal/High
Other
* Look for Blood Loss.
* May be Normocytic and Lost of Weight
* Give Pyridoxine (B6) to see if responsive
* Check HbA2, HbF levels.
The CBC and The Reticulocyte Count (T.R.C) can divide the anemias in: T.R.C < 2.5 = R.B.C Morphology Anemias.
T.R.C > 2.5 = Hemolysis/Hemorrhage Anemias
Morphology Anemias we divide according with M.C.V. (Mean Corpuscular Volume): Normal Value 80-100 ųm³.
In that way we can have the following Morphology Anemias: Normocytic Normochromic, Micro or Macrocytic.
Normocytic Normochromic (Hypoproliferative) can be: 1) Marrow Damage: Infiltration/Fibrosis, Aplasia. 2) Iron Deficiency.
3) Decrease Stimulation: Inflammation, Metabolic Defect, Renal Disease.
Micro or Macrocytic Anemias (Maturation Disorder) we have: 1) Cytoplasmic Defects and 2) Nuclear Defects
Cytoplasmic Defects examples are: Iron deficency Anemia, Thalasemias, Sideroblastic Anemia.
Nuclear Defects examples are: Folate Deficiency, Vit B12 deficiency, Drug Toxicity, Refractory Anemia.
Most of Macrocytic Anemias are caused by Processes that interfere with normal DNA synthesis and replication.
Hemolysis/Hemorrhage Anemias = Hemolytic Anemias (T.R.C >2.5). Can have different causes, like: Blood Loss, Intravascular Hemolysis
Another causes of Hemolytic: Metabolic Defect, Membrane Abnormality, Hemoglobinopathy, Autoimmune Defect, Fragmentation Hemolysis