01-27-2018, 11:34 AM
We have the following:
1) Acute hemorrhage, 2) Enzyme defects (e.g. G6PD deficiency, PK deficiency). 3) RBC membrane defects (e.g. hereditary spherocytosis)
4) Bone marrow disorders (e.g. aplastic anemia, leukemia). 5) Hemoglobinopathies (e.g. sickle cell disease)
6) Autoimmune hemolytic Anemia, 7) Anemia of chronic disease (ACD) - TIBC ↓, Ferritin ↑, Storage iron in marrow macrophages ↑.
THINGS TO REMEMBER: Serum haptoglobin ↓ and serum LDH ↑ indicate RBC hemolysis.
THINGS TO REMEMBER: Coombs' test is used to distinguish between immune vs non-immune mediated RBC hemolysis
1) Acute hemorrhage, 2) Enzyme defects (e.g. G6PD deficiency, PK deficiency). 3) RBC membrane defects (e.g. hereditary spherocytosis)
4) Bone marrow disorders (e.g. aplastic anemia, leukemia). 5) Hemoglobinopathies (e.g. sickle cell disease)
6) Autoimmune hemolytic Anemia, 7) Anemia of chronic disease (ACD) - TIBC ↓, Ferritin ↑, Storage iron in marrow macrophages ↑.
THINGS TO REMEMBER: Serum haptoglobin ↓ and serum LDH ↑ indicate RBC hemolysis.
THINGS TO REMEMBER: Coombs' test is used to distinguish between immune vs non-immune mediated RBC hemolysis