08-19-2018, 07:35 PM
Wolff-Parkinson-White syndrome is a pre-excitation syndrome wherein an extra conduction pathway/accessory pathway (aka the bundle of Kent) leads to arrhythmias marked by the characteristic delta wave with shortened PR interval on ECG.
Symptoms range from asymptomatic, to palpitations and vague complaints, to sudden death from tachyarrhythmias that prevent ventricular filling
Wolff-Parkinson White syndrome is diagnosed by ECG with a:
• Shortened PR interval
• Widened QRS complex
• Delta wave (which signifies early ventricular depolarization)
The definitive surgical treatment of Wolff-Parkinson-White syndrome is radiofrequency ablation of the accessory pathway.
Brugada syndrome is most commonly caused by a genetic disorder of cardiac sodium channels that leads to an increased risk of ventricular tachyarrhythmias and sudden cardiac death.
Brugada syndrome is an autosomal dominant disorder most common in Asian males.
ST segment elevation >2mm in >1 of V1-V3 followed by a negative T wave is the only ECG abnormality that is potentially diagnostic in Brugada syndrome.
The only proven therapy for Brugada syndrome is an implantable cardioverter-defibrillator (ICD).