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22.
An 18-year-old man attempts suicide by taking 15 g of acetaminophen. Four hours after the overdose, high levels of acetaminophen are found in the plasma. The most appropriate therapy is
a)haemodialysis
b)oral aspirin
c)oral n acetlyl cysytein
d)respiratory support and watchful waiting
e)urinary alkalinization and forced diuresis
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Paracetamol overdose
Intravenous acetylcysteine is indicated for the treatment of paracetamol (acetaminophen) overdose. Oral acetylcysteine for this indication is uncommon as it is poorly tolerated owing to the high doses required (due to poor oral bioavailability), unpleasant taste/odour and adverse drug reactions (particularly nausea and vomiting).
For this indication, acetylcysteine acts to augment glutathione reserves (depleted by toxic paracetamol metabolites) in the body and, together with glutathione to directly bind to toxic metabolites. These actions serve to protect hepatocytes in the liver from toxicity due to paracetamol overdose.
[edit]
I think the answer is hemodialysis.
oral acetylcysteine is of no use here.
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Methionine is used as Oral antidote used for Acetaminophen overdosage and not N-Acetyl cysteine which is used Intravenous.
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At least, you don't need to do hemodialysis for 15g Acetaminophen overdose.
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"Oral N-acetylcysteine is the only FDA approved antidote for acetaminophen overdose in the United States", i found this in the web/
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do u think 15 g is too less...
