02-26-2007, 10:37 PM
A man and woman are both affected by an autosomal dominant disorder that has 80% penetrance in all affected individuals. What is the probability that they will produce phenotypically normal offspring?
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autosomal - ulise
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02-26-2007, 10:52 PM
If u have 80% penetrance--that's mean that 20% chances to transmit the good gene =0.2
If both parents have the same AD disease with the same penetrance, the chance for a kid to be healty is 0,2x0,2=0.04====>>>4% i m right??? I m not sure since i didnt repeat the genetics stuff recently..
02-26-2007, 10:57 PM
40%
Normal with both parent AD, you've got 25% offspring normal phnotype, but with 80% penetrance, you will get additional (1-25%)X(1-)80%=15%, so in total it will be 40%
02-26-2007, 10:58 PM
 i will wait for a good explanation...since then i think a must review that section in genetics (
02-26-2007, 11:01 PM
well Quansar you are right: about the 40%
there is 75% chance of having sick kids x80% pentrance=60% sick kids 100%-60%=40% normal |
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